PREDIABETES Type 2 diabetes is developed over a long period of time and typically it goes through a phase called pre-diabetes for several years. Department of Health and Human Services (DHHS) and American Diabetes Association (ADA) introduced this relatively new term “pre-diabetes” in 2002 to bring awareness amongst physicians and in general population. One of the reasons for renaming prediabetes from its former clinical name of impaired glucose tolerance was to highlight the seriousness of the condition and to motivate people to get appropriate treatment. As the name suggests, prediabetes is defined as a condition that precedes type 2 diabetes. It’s also called impaired glucose tolerance (IGT) or impaired fasting glucose (IFG), depending on the test used to diagnose it with. People with prediabetes have higher than normal blood glucose levels, but they aren’t elevated enough to be diagnosed as diabetes. A fasting plasma glucose value between 100 to 125 mg/dl or more indicates impaired fasting glucose (IFG). In an oral glucose tolerance test, plasma glucose values between 140 to 199 mg/dl at 2 hours post-glucose load indicates impaired glucose tolerance (IGT). According to the recently released National Diabetes Fact Sheet 2005 by CDC that 20.8 and 41 millions of Americans are suffering from diabetes and pre-diabetes respectively. The estimated total cost of diabetes in 2002 is 132 billion dollars for a total of 18.2 million diabetics. It clearly demonstrates an increasing trend and from 2002 the prevalence rates of diabetes has increased by 12.5%. From the CDC Diabetes Fact Sheet and the literature it is evident that damage to the body already started taking place during pre-diabetes stage. In other words as the insulin resistance is gradually developing the blood sugar levels rise, which in turn results in a gamut of health problems like high blood pressure, increased risk of heart attacks, neuropathy, nephropathy, blindness, etc. Thus it not only affects the quality of life but also have a significant impact on personal and Government finances. An important outcome of the landmark studies of Diabetes Prevention Program is that diabetes can be prevented by intensive lifestyle modification (healthy diet and exercise) amongst high-risk adults. Just by changing lifestyle alone the success rate of prevention was achieved by 58% and by taking medication with Metformin the success rate was a moderate 31% over three years. However, to general population it is not enough to say eat healthy diet and exercise daily. In order to achieve higher degree of success they need to be educated, motivated, empowered to make knowledgeable decisions on taking medicines and/or supplements to complement with lifestyle changes. At present no FDA approved drugs are available in the market specifically for PREVENTION of insulin resistance or pre-diabetes and type 2 diabetes. Pre-diabetes and type 2 diabetes can be slowed, stopped, and even reversed with early intervention, lifestyle adjustments (eating healthy foods, regular exercise) and nutraceutical supplements. SAI Nutraceuticals has done extensive research in this area and worked with the experts to understand the mechanism of several nutraceuticals in prevention and/or managing prediabetes. SAI Pre-diabeatsTM Lowers Glycemic Response of High Sugar Meal Actions to prevent Prediabetes and Action Sites of Pre-diabeatsTM